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ADHD Medication During Pregnancy and Breastfeeding

psychology-today-logo.pngWomen suffering from ADHD must make a difficult decision about whether to continue or stop taking ADHD medication during pregnancy and breast-feeding. There is a lack of information about how long-term exposure to these medications can affect the foetus.

coe-2023.pngA study recently published in Molecular Psychiatry demonstrates that children exposed to ADHD medication during pregnancy do not develop neurological issues such as hearing loss or vision, febrile seizures, or IQ impairment. The authors acknowledge the need for more high-quality studies.

Risk/Benefit Analysis

Women who are pregnant and taking ADHD medication should evaluate the benefits of using it against the possible risks for the foetus. Physicians do not have the data needed to make unequivocal recommendations however they can provide information about risks and benefits that assist pregnant women in making informed decisions.

A study published in Molecular Psychiatry found that women who were taking ADHD medications in early pregnancy did not face an higher risk of fetal cardiac malformations or major structural birth defects. The researchers used a large population-based case-control study to evaluate the incidence of major structural birth defects in infants born to mothers who took stimulants during early pregnancy and those who had not. Pediatric cardiologists and clinical geneticists examined the cases to ensure accurate classification of the cases and to reduce the possibility of bias.

However, the study had its limitations. Researchers were unable, in the first place to differentiate the effects caused by the medication from the disorder. This limitation makes it difficult for researchers to determine if the small associations observed among the groups exposed were due to the use of medications, or if they were caused by co-morbidities. The researchers did not examine long-term outcomes for offspring.

The study revealed that infants whose mothers took ADHD medication during pregnancy had a slightly higher risk of admission to the neonatal care unit (NICU), compared to those whose mothers did not use any medication during pregnancy, or had discontinued taking their medication prior to or during pregnancy. This was due to central nervous system disorders. The higher risk of admission was not influenced by the stimulant medications used during pregnancy.

Women who were taking stimulant ADHD medication during pregnancy also had an elevated chance of having a caesarean birth or having a baby born with an low Apgar score (less than 7). These risks did not appear to be affected by the kind of medication used during pregnancy.

Researchers suggest that the minor risk of using ADHD medications in early pregnancies may be offset by the greater benefits to both mother and baby of continuing treatment for the woman's condition. Physicians should discuss this with their patients and, when possible, help them develop strategies to improve coping skills that can lessen the effects of her disorder on her daily functioning and relationships.

Medication Interactions

As more women than ever before are being diagnosed with ADHD and being treated with medication, the question of whether or not to discontinue treatment during pregnancy is a question that more and more physicians confront. Most of the time, these decisions are made in the absence of clear and authoritative evidence either way, so physicians must weigh their knowledge from their own experiences, those of other doctors, and what research suggests on the subject and their own best judgment for each patient.

The issue of possible risks to the infant can be difficult to determine. Many of the studies on this issue are based on observational evidence instead of controlled research and their findings are often contradictory. The majority of studies limit their analysis to live-births, which could underestimate the severity of teratogenic effects leading to terminations or abortions of pregnancy. The study discussed in this journal club addresses these shortcomings by analyzing data on live and deceased births.

The conclusion: While some studies have found an association between ADHD medications and the possibility of certain birth defects, others have found no connection, and most studies demonstrate a neutral or slight negative effect. As a result, a careful risk/benefit assessment must be conducted in every case.

It can be challenging, if not impossible, for women suffering from ADHD to stop taking their medication. In a recent article published in Archives of Women's Mental Health by psychologist Jennifer Russell, she notes that stopping ADHD medications during pregnancy can increase depression and feelings of being isolated. The loss of medication can affect the ability to drive safely and perform work-related tasks, which are essential aspects of everyday life for those suffering from ADHD.

She recommends women who are unsure about whether or not to stop medication in light of their pregnancy, consider informing family members, friends, and coworkers on the condition, its effects on daily functioning, and on the advantages of continuing the current treatment regimen. Educating them can also help the woman feel supported in her struggle with her decision. Certain medications can pass through the placenta. If a woman decides to not take her adhd medication without prescribing medication while pregnant and breastfeeding, it's important to be aware that the drug could be passed on to her infant.

Risk of Birth Defects

As the use and abuse of ADHD medications to treat the symptoms of attention deficit disorder hyperactivity disorder (ADHD) increases the concern over the potential adverse effects of the drugs on fetuses. Recent research published in the journal Molecular Psychiatry has added to the body knowledge on this topic. With two massive data sets researchers were able to look at more than 4.3 million pregnancies and determine whether the use of stimulant medications increased the risk of birth defects. While the overall risk is low, the researchers found that exposure in the first trimester to ADHD medicines was associated with a slightly higher rate of certain heart defects, like ventriculo-septal defects (VSD).

The researchers behind the study found no connection between the use of early medications and other congenital abnormalities, like facial clefting, or club foot. The results are in line with previous studies that have shown a small but significant increase in the risk of cardiac malformations among women who started taking ADHD medications prior to pregnancy. The risk was higher during the latter part of pregnancy, as many women are forced to stop taking their ADHD medications.

Women who took ADHD medication in the first trimester of their pregnancies were also more likely to undergo a caesarean section, a low Apgar score after delivery and a baby who required breathing assistance at birth. However the researchers types Of adhd medication the study were unable to eliminate selection bias by restricting the study to women who didn't have any other medical conditions that could have contributed to these findings.

Researchers hope that their research will provide doctors with information when they encounter pregnant women. The researchers suggest that while discussing risks and benefits are important, the choice about whether to continue or stop medication should be based on the severity of each woman's ADHD symptoms and her requirements.

The authors also warn that while discontinuing the medications is an option, it isn't an option that is recommended due to the high rate of depression and other mental health issues for women who are expecting or recently postpartum. Further, research shows that women who stop taking their medications will have a difficult time adjusting to a life without them after the baby is born.

Nursing

It can be a stressful experience to become a mom. Women who suffer from ADHD who have to manage their symptoms while attending doctor appointments as well as preparing for the arrival of a child and adjusting to new household routines can experience severe challenges. Many women opt to continue taking their ADHD medication during pregnancy.

The risk to a breastfeeding infant is minimal because the majority of stimulant medications is absorbed through breast milk at low levels. However, the rate of medication exposure to the newborn can vary depending on the dosage, frequency it is administered and the time of the day it is administered. In addition, individual medications enter the body of the baby differently through the gastrointestinal tract and breast milk. The impact of this on a newborn infant is not well understood.

Because of the lack of research, some physicians might be tempted to stop taking stimulant medication during the course of pregnancy. This is a difficult decision for the mother, who must weigh the advantages of continuing her medication against the risk to the fetus. As long as more information is available, GPs can inquire about pregnant patients if they have a history of ADHD or if they plan to take medication in the perinatal stage.

Numerous studies have proven that women can continue to take their ADHD medication without risk during pregnancy and breast-feeding. In response, an increasing number of patients are choosing to continue their medication. They have discovered, in consultation with their physicians, that the benefits of keeping their current medication outweigh any potential risks.

Women with ADHD who are planning to nurse should seek the advice of an expert psychiatrist prior to becoming pregnant. They should discuss the medication they are taking with their physician as well as the pros and cons of continuing treatment. This includes non-pharmacological methods. Psychoeducation is also required to help pregnant women suffering from ADHD be aware of the symptoms and underlying disorder. They should also be educated about treatment options and build strategies for coping. This should be a multidisciplinary process with the GPs, obstetricians, and psychiatrists. Pregnancy counseling should consist of a discussion of a treatment plan for the mother and the child, and monitoring for signs of deterioration, and, if needed, adjustments to the medication regimen.
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